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Tom Maguire's avatar

Re: "She also briefly refers to an appendectomy in one sentence that stands out to me as if written in neon font. I’m growing conspiracy-minded about appendices.

Hands up if you have colon cancer and also had appendicitis as an adult.

I’ve asked ChatGPT about this and there is apparently no connection. But I still don’t believe it, which I guess is what it means to be conspiracy-minded."

"Trust your gut" seems like awkward advice here, but you are right and ChatGPT needs to go back to whatever it is good at.

Google Gemini kicks back a "Yes, there is a link" answer and provides published papers.

Google search: "association of appendicitis with colon cancer"

First paragraph of Gemini:

AI Overview

While acute appendicitis is not a direct cause of colon cancer, there's an observed association where patients with appendicitis, particularly those over 40, have a significantly higher risk of being diagnosed with colon cancer in the subsequent year, especially within the first six months after the appendicitis diagnosis. This suggests that appendicitis might be an early indicator of underlying colon cancer, rather than the other way around, according to Advocare Colon & Rectal Surgical Specialists.

A couple of links:

Increased Risk:

Studies have shown that patients treated for appendicitis have a roughly four times higher risk of developing colon cancer within the first year compared to those without appendicitis, according to The Lancet. This risk is even higher in the first six months after the appendicitis diagnosis.

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00373-5/

Age Matters:

The risk is particularly pronounced in individuals over 40, says ScienceDirect.com. Younger patients (under 40) also face an elevated risk, though the increase is less dramatic, according to Advocare Colon & Rectal Surgical Specialists.

https://www.sciencedirect.com/science/article/pii/S2589537023003735

To Be Fair: Even the greatly elevated risk is low. In the second linked paper, among the group with appendicitis, 5-10 per 10,000 got colon cancer; in the control group it was 1 in 10,000. But they do recommend that anyone with appendicitis get screened for colon cancer.

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